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Nicotine Tob Res. 2009 Apr;11(4):342-7. doi: 10.1093/ntr/ntp027. Epub 2009 Apr 3.

A pilot study of nicotine delivery to smokers from a metered-dose inhaler.

Author information

1
Department of Medicine, School of Medicine and Health Sciences, University of Otago, Wellington, Wellington South, New Zealand.

Abstract

INTRODUCTION:

The present study generated preliminary data on the acceptability and pharmacokinetics of nicotine administered by a simple metered-dose inhaler (MDI).

METHODS:

We conducted a nonrandomized, open-label cross-over trial of 10 current smokers. On Day 1, a single cigarette was smoked ad libitum. On Day 2, participants took 10 puffs (20 inhalations) of 50 microg nicotine/puff through the inhaler, and on Day 3, they took 10 puffs (20 inhalations) of 100 microg nicotine/puff, each over 5 min. Nicotine pharmacokinetics, changes in heart rate and blood pressure, and the acceptability of the inhalers were measured and recorded.

RESULTS:

Nicotine administered by an MDI produced a median maximum plasma concentration that was about 50% of that obtained by smoking a cigarette (12.5 vs. 25.9 ng/ml) and took twice the time to reach that concentration, 6 versus 3 min. Self-rated satisfaction and reduced urge to smoke were similar for the MDIs and a cigarette.

DISCUSSION:

The results suggest that nicotine can be delivered effectively by the pulmonary route using a standard MDI. The inhaler appears to provide a satisfaction level and reduction in the urge to smoke relatively similar to that provided by smoking a cigarette. These conclusions require verification in a larger controlled study.

PMID:
19346511
DOI:
10.1093/ntr/ntp027
[Indexed for MEDLINE]

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