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Am J Obstet Gynecol. 2009 Jul;201(1):33.e1-6. doi: 10.1016/j.ajog.2009.02.004. Epub 2009 Apr 5.

Loop electrosurgical excision of the cervix and subsequent risk for spontaneous preterm delivery: a population-based study of singleton deliveries during a 9-year period.

Author information

1
Institute of Cancer Epidemiology, Danish Cancer Society, Juliane Marie Centre, Rigshospitalet, Copenhagen, Denmark.

Abstract

OBJECTIVE:

Our aim was to assess the association between loop electrosurgical excision procedure (LEEP) and the subsequent risk for spontaneous preterm delivery, with the use of population-based data from various nationwide registries.

STUDY DESIGN:

The study population consisted of all singleton deliveries in Denmark during a 9-year period, 1997-2005. Information on the deliveries that included different cervical procedures was obtained from various national registries. In all, 552,678 deliveries were eligible for analyses.

RESULTS:

Of the deliveries in which the mother had no previous LEEP, 18,519 deliveries (3.5%) were preterm; when this data were applied to 530 preterm deliveries (6.9%) that were subsequent to LEEP, the yield was a significantly increased risk of preterm delivery, with an odds ratio of 2.07 (95% CI, 1.88-2.27; LEEP vs no LEEP).

CONCLUSION:

Our study showed an overall 2-fold increase in the risk of spontaneous preterm delivery in singleton deliveries subsequent to LEEP treatment, even after adjustment for various potential risk factors.

PMID:
19345930
DOI:
10.1016/j.ajog.2009.02.004
[Indexed for MEDLINE]

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