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Phytochemistry. 2009 Mar;70(5):684-8. doi: 10.1016/j.phytochem.2009.02.012. Epub 2009 Apr 3.

Antibacterial endiandric acid derivatives from Beilschmiedia anacardioides.

Author information

1
Department of Organic Chemistry, University of Yaounde 1, PO Box 812, Yaoundé, Cameroon.

Abstract

Three endiandric acid derivatives, beilschmiedic acids A, B and C were isolated from the stem bark of Beilschmiedia anacardioides together with the known beta-sitosterol. Their structures were established by means of modern spectroscopic techniques. The relative configuration of compound 1 was determined by single crystal X-ray analysis. The antibacterial activities of compounds A,B,C were evaluated in vitro against five strains of microbes. Compound C showed strong activity against Bacillus subtilis, Micrococcus luteus and Streptococcus faecalis (MICs below 23 microM). This Compound was more active than the reference antibiotic ampicillin against B. subtilis and M. luteus.

PMID:
19345383
DOI:
10.1016/j.phytochem.2009.02.012
[Indexed for MEDLINE]

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