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FEBS Lett. 2009 May 6;583(9):1489-92. doi: 10.1016/j.febslet.2009.03.066. Epub 2009 Apr 2.

Glutathione and gamma-glutamyl transferases are involved in the formation of cadmium-glutathione complex.

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  • 1Dep. BioquĂ­mica, IQ, UFRJ, 21941-909 Rio de Janeiro, Brazil.


In a wild-type strain of Saccharomyces cerevisiae, cadmium induces the activities of both gamma-glutamyl transferase (gamma-GT) and glutathione transferase 2 (Gtt2). However, Gtt2 activity did not increase under gamma-GT or Ycf1 deficiencies, suggesting that the accumulation of glutathione-cadmium in the cytosol inhibits Gtt2. On the other hand, the balance between the cytoplasmic and vacuolar level of glutathione seems to regulate gamma-GT activity, since this enzyme was not activated in a gtt2 strain. Taken together, these results suggest that gamma-GT and Gtt2 work together to remove cadmium from the cytoplasm, a crucial mechanism for metal detoxification that is dependent on glutathione.

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