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Cell. 2009 Apr 3;137(1):32-45. doi: 10.1016/j.cell.2009.03.023.

The vertebrate primary cilium in development, homeostasis, and disease.

Author information

1
McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract

Cilia are complex structures that have garnered interest because of their roles in vertebrate development and their involvement in human genetic disorders. In contrast to multicellular invertebrates in which cilia are restricted to specific cell types, these organelles are found almost ubiquitously in vertebrate cells, where they serve a diverse set of signaling functions. Here, we highlight properties of vertebrate cilia, with particular emphasis on their relationship with other subcellular structures, and explore the physiological consequences of ciliary dysfunction.

PMID:
19345185
PMCID:
PMC3016012
DOI:
10.1016/j.cell.2009.03.023
[Indexed for MEDLINE]
Free PMC Article

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