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Diagn Microbiol Infect Dis. 2009 Jun;64(2):229-32. doi: 10.1016/j.diagmicrobio.2009.02.001. Epub 2009 Apr 2.

Rapid detection of the poly-gamma-D-glutamic acid capsular antigen of Bacillus anthracis by latex agglutination.

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  • 1Department of Microbiology and Immunology, University of Nevada School of Medicine, Reno, 89557, USA.


Latex agglutination has been used to detect capsular polysaccharides from a variety of bacteria in body fluids. A latex agglutination assay was constructed for detection of the poly-gamma-D-glutamic acid (gammaDPGA) capsular polypeptide of Bacillus anthracis in serum from animal models of pulmonary anthrax. The assay was able to detect gammaDPGA in serum from infected animals at concentrations of 100 to 200 ng/mL.

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