Format

Send to

Choose Destination
See comment in PubMed Commons below
Br J Haematol. 2009 Jun;145(6):709-27. doi: 10.1111/j.1365-2141.2009.07669.x. Epub 2009 Mar 30.

Update in understanding common variable immunodeficiency disorders (CVIDs) and the management of patients with these conditions.

Author information

1
Department of Clinical Immunology, Oxford Radcliffe Hospitals, Oxford, UK. helen.chapel@ndm.ox.ac.uk

Abstract

The common variable immunodeficiency disorders are a mixed group of heterogeneous conditions linked by lack of immunoglobulin production and primary antibody failure. This variability results in difficulty in making coherent sense of either immunopathogenesis or the role of various genetic abnormalities reported in the literature. The recent attempt to collate the varied complications in these conditions and to define particular clinical phenotypes has improved our understanding of these diseases. Once refined and confirmed by other studies, these definitions will facilitate improved accuracy of prognosis and better management of clinical complication. They may also provide a method of analysing outcomes as related to new immunopathological and genetic findings.

PMID:
19344423
PMCID:
PMC2718064
DOI:
10.1111/j.1365-2141.2009.07669.x
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Support Center