Format

Send to

Choose Destination
See comment in PubMed Commons below
Br J Haematol. 2009 May;145(4):524-8. doi: 10.1111/j.1365-2141.2009.07630.x. Epub 2008 Mar 13.

Chronic transfusion practice for children with sickle cell anaemia and stroke.

Author information

1
St Jude Children's Research Hospital, Memphis, TN 38105-3678, USA. banu.aygun@stjude.org

Abstract

Chronic transfusions to maintain haemoglobin S (HbS) < or =30% are the mainstay of treatment for children with sickle cell anaemia (SCA) and previous stroke. This HbS target is often hard to maintain, however, and values achieved in current practice are unknown. In preparation for the Phase III Stroke With Transfusions Changing to Hydroxyurea (SWiTCH) trial, we collected data on 295 children with SCA and stroke who received transfusions at 23 institutions. The overall average pre-transfusion %HbS was 35 +/- 11% (institutional range 22-51%). Receiving scheduled transfusions on time was the most predictive variable for maintaining HbS at the < or =30% goal.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center