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J Pediatr Endocrinol Metab. 2009 Jan;22(1):47-53.

Facial metrics in children with corticotrophin-producing pituitary adenomas suggest abnormalities in midface development.

Author information

1
Pediatric Endocrinology Inter-Institute Training Program, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

BACKGROUND:

Tumors of the hypothalamic-pituitary unit have been linked to genetic syndromes that are associated with midfacial abnormalities.

AIM:

We hypothesized that mutations of genes that affect the development of the face (and consequently of the anterior pituitary) may be present in children with ACTH-producing pituitary adenomas, and if this is true then facial measurements would be different from those predicted by parental features.

METHODS:

We studied 20 children with corticotropinomas and a control group and their parents. All facial measurements were expressed according to standard deviation scores.

RESULTS:

Significant differences were seen between the children with pituitary adenomas and their parents for vertical facial height measures: nasal length (p < 0.001), lower facial height (p < 0.03) and overall facial height (p < 0.01).

CONCLUSION:

We conclude that some of the indices of midline craniofacial development, in particular those affecting the vertical axis, are different in children with corticotroph adenomas producing ACTH.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00001595.

PMID:
19344074
PMCID:
PMC3143028
[Indexed for MEDLINE]
Free PMC Article
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