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J Pediatr Ophthalmol Strabismus. 2009 Mar-Apr;46(2):87-90; quiz 91-2.

Levodopa/carbidopa in the treatment of amblyopia.

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Guru Nanak Eye Center, Maulana Azad Medical College, Delhi, India.



To evaluate the role of levodopa/carbidopa in the treatment of amblyopia.


Thirty patients with strabismic amblyopia between the ages of 3 and 12 years were part of this double-blind, randomized study. Patients were divided into two groups. Group A received 0.50 mg + 1.25 mg of levodopa/carbidopa per kilogram body weight three times daily after meals, with a protein rich drink, whereas Group B received placebo. Both groups received full-time conventional occlusion until a visual acuity of 6/6 was achieved or for a maximum of 3 months.


The authors observed more than two lines improvement in visual acuity that was greater in the levodopa group (15 of 15) than in the placebo group (9 of 15) (P < .005). Furthermore, improvement in visual acuity of more than two lines was greater in patients younger than 8 years (100%) than in patients older than 8 years of age (60%) (P = .0026). There was also no significant reversal of the improved visual acuity in up to 6 months of follow-up.


Levodopa/carbidopa improves visual acuity in patients with amblyopia and maintains improved visual acuity, especially in patients younger than 8 years.

[Indexed for MEDLINE]

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