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Pediatr Blood Cancer. 2009 Jul;53(1):28-32. doi: 10.1002/pbc.22013.

Wilms tumour and paternal occupation: an analysis of data from the National Registry of Childhood Tumours.

Author information

1
Academic Centre for Defence Mental Health, King's College London, Institute of Psychiatry, Weston Education Centre, London, United Kingdom. nicola.fear@iop.kcl.ac.uk

Abstract

BACKGROUND:

Wilms tumour is an embryonal malignant tumour that accounts for 90% of childhood kidney cancers. Parental occupational exposure has been hypothesised to be a cause of childhood Wilms tumour, in particular exposure to pesticides. However, the findings are inconsistent.

PROCEDURE:

We have examined the association between paternal occupational exposures and Wilms tumour using birth registration data for cases (n = 2568) from the National Registry of Childhood Tumours (NRCT) and matched controls (n = 2,568) drawn from the general population of Great Britain. Paternal occupation, as recorded at the time of birth, was used to infer "occupational exposure" using a previously defined occupational exposure classification scheme. Odds ratios and 95% confidence intervals were generated using conditional logistic regression with exact methods to estimate the association between each paternal occupational exposure group and childhood Wilms tumour.

RESULTS:

All odds ratios were close to 1.00 and no statistically significant associations were observed.

CONCLUSION:

The results of this study failed to support any of the previously identified associations between paternal occupation and childhood Wilms tumour.

PMID:
19343797
DOI:
10.1002/pbc.22013
[Indexed for MEDLINE]

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