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Nat Rev Cancer. 2009 May;9(5):361-71. doi: 10.1038/nrc2628. Epub 2009 Apr 3.

Tumour necrosis factor and cancer.

Author information

  • 1Centre for Cancer and Inflammation, Institute of Cancer, Barts, UK. Frances.balkwill@cancer.org.uk

Abstract

Tumour necrosis factor (TNF) is a major inflammatory cytokine that was first identified for its ability to induce rapid haemorrhagic necrosis of experimental cancers. When efforts to harness this anti-tumour activity in cancer treatments were underway, a paradoxical tumour-promoting role of TNF became apparent. Now that links between inflammation and cancer are appreciated, is TNF a target or a therapeutic in malignant disease -- or both?

PMID:
19343034
DOI:
10.1038/nrc2628
[PubMed - indexed for MEDLINE]
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