Format

Send to

Choose Destination
See comment in PubMed Commons below
Cell Cycle. 2009 May 1;8(9):1329-31. Epub 2009 May 23.

TCAB1: driving telomerase to Cajal bodies.

Author information

1
Department of Medicine, Stanford School of Medicine, Stanford, CA 94305, USA.

Abstract

Telomerase supports the proliferation of progenitor cells and tumor cells by adding telomere repeats to chromosome ends. The low abundance and restricted expression pattern of telomerase have limited our knowledge of this important enzyme. A new telomerase protein, TCAB1, sheds light on the pathway that governs telomerase holoenzyme assembly and function in vivo. TCAB1 is a component of active telomerase and is required for the telomerase holoenzyme to accumulate in Cajal bodies and to elongate telomeres. These findings provide important new insights into how telomerase functions in cancer and in stem cell biology.

PMID:
19342896
DOI:
10.4161/cc.8.9.8288
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Taylor & Francis
    Loading ...
    Support Center