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Curr Opin Immunol. 2009 Feb;21(1):111-7. doi: 10.1016/j.coi.2009.03.004. Epub 2009 Apr 1.

Antigen presentation in celiac disease.

Author information

1
Centre for Immune Regulation, Institute of Immunology, Rikshospitalet University Hospital and University of Oslo, Norway. s.w.qiao@medisin.uio.no

Abstract

Celiac disease is caused by an inappropriate immune response to ingested gluten proteins. As a dietary antigen, gluten undergoes extensive but incomplete proteolytic digestion in the intestinal lumen. The resultant peptide fragments of gluten require deamidation, but not necessarily further intracellular processing for presentation. Recent studies reveal why the disease associated HLA-DQ2 molecule is particularly suited for binding proline-rich gluten peptides. In comparison, DQ8 exhibits different binding characteristics, which may explain the lesser risk for disease in association with this molecule.

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PMID:
19342211
PMCID:
PMC3901576
DOI:
10.1016/j.coi.2009.03.004
[Indexed for MEDLINE]
Free PMC Article

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