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Chem Pharm Bull (Tokyo). 1991 Jun;39(6):1612-4.

Pharmacokinetics of [6]-gingerol after intravenous administration in rats.

Author information

1
Department of Pharmacy, Shimane Medical University Hospital, Japan.

Abstract

A high-performance liquid chromatographic method to determine [6]-gingerol, a pungent constituent of ginger, in rat plasma was developed and a pharmacokinetic study was performed in rats. Quantitative analysis with high reproducibility was achieved for [6]-gingerol over the concentration range of 0.2-40 micrograms/ml. After bolus intravenous administration at a dose of 3 mg/kg, the plasma concentration-time curve was described by a two-compartment open model. [6]-Gingerol was rapidly cleared from plasma with a terminal half-life of 7.23 min and a total body clearance of 16.8 ml/min/kg. Serum protein binding of [6]-gingerol was 92.4%.

PMID:
1934184
[Indexed for MEDLINE]

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