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Cell Stem Cell. 2009 Apr 3;4(4):280-2. doi: 10.1016/j.stem.2009.03.006.

Fishing for a WNT-PGE2 link: beta-catenin is caught in the stem cell net-work.

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1
Department of Surgery, Weill Cornell Medical College, Cornell University, New York, NY 10021, USA. tre2003@med.cornell.edu

Abstract

WNT and PGE2 signaling pathways are each associated with stem cell activity in the hematopoietic system. In a recent issue of Cell, Goessling et al. (2009) use the zebrafish model to reveal a conserved PKA-dependent mechanism that connects the two pathways via beta-catenin, enhancing stem cell proliferation and tissue regeneration.

PMID:
19341616
DOI:
10.1016/j.stem.2009.03.006
[Indexed for MEDLINE]
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