Format

Send to

Choose Destination
See comment in PubMed Commons below
Head Neck. 2009 Aug;31(8):1049-55. doi: 10.1002/hed.21070.

Growth inhibition of head and neck carcinomas by D-allose.

Author information

1
Department of Otorhinolaryngology, Faculty of Medicine, Kagawa University, Kagawa, Japan. mitanit@med.kagawa-u.ac.jp

Abstract

BACKGROUND:

An inhibitory effect of D-allose, a rare sugar, on several cancer cell lines has been reported. This study aimed to investigate the growth inhibition of head and neck squamous cell carcinoma cells by D-allose.

METHODS:

We treated 3 head and neck carcinoma cell lines with D-allose, D-fructose, D-psicose, and D-glucose. Cell growth assays as well as analyses of messenger RNA (mRNA) expression, cell cycle, apoptosis, and uptake of 14C-glucose were performed.

RESULTS:

D-allose had inhibitory effects on all 3 cell lines and tended to upregulate mRNA expression of glucose transporters, p21 and p53, and downregulate mRNA expression of cyclin A2, cyclin B1, and CDC2. We observed that D-allose tended to interfere with the intracellular uptake of D-glucose and induced apoptosis.

CONCLUSION:

Our results indicate that D-allose inhibits the growth of head and neck squamous cell carcinoma cells. D-allose has a considerable potential as a new anticancer agent in those patients.

PMID:
19340872
DOI:
10.1002/hed.21070
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center