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Bioorg Med Chem Lett. 2009 May 1;19(9):2514-8. doi: 10.1016/j.bmcl.2009.03.029. Epub 2009 Mar 14.

Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3).

Author information

1
Department of Medicinal Chemistry, Merck Research Laboratories, Sumneytown Pike, PO Box 4, West Point, PA 19486, USA.

Abstract

A series of amiloride derivatives modified at the 5-position of the pyrazine ring were evaluated as inhibitors of acid-sensing ion channel-3 (ASIC3), a novel target for the treatment of chronic pain.

PMID:
19339181
DOI:
10.1016/j.bmcl.2009.03.029
[Indexed for MEDLINE]

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