Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2009 May 1;19(9):2570-3. doi: 10.1016/j.bmcl.2009.03.026. Epub 2009 Mar 14.

Synthesis of novel thiourea, thiazolidinedione and thioparabanic acid derivatives of 4-aminoquinoline as potent antimalarials.

Author information

1
Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226 001, India.

Abstract

In search of new 4-aminoquinolines which are not recognized by CQR mechanism, thiourea, thiazolidinedione and thioparabanic acid derivatives of 4-aminoquinoline were synthesized and screened for their antimalarial activities. Thiourea derivative 3 found to be the most active against CQ sensitive strain 3D7 of Plasmodium falciparum in an in vitro model with an IC(50) of 6.07ng/mL and also showed an in vivo suppression of 99.27% on day 4 against CQ resistant strain N-67 of Plasmodium yoelii.

PMID:
19339178
DOI:
10.1016/j.bmcl.2009.03.026
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center