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Nat Genet. 2009 Apr;41(4):385-6.

Somatic and germline genetics at the JAK2 locus.

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1
Wellcome Trust Sanger Institute, Hinxton, UK. pc8@sanger.ac.uk

Abstract

Myeloproliferative neoplasms are hematological malignancies frequently associated with somatically acquired mutation of the JAK2 gene. A new study shows that these mutations are preferentially found within a particular inherited JAK2 haplotype, implying the existence of a strong, but uncharacterized, interaction between somatic and germline genetics at this locus.

PMID:
19338077
[Indexed for MEDLINE]
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