Format

Send to

Choose Destination
Nat Cell Biol. 2009 Apr;11(4):377-9. doi: 10.1038/ncb0409-377.

Skp2: caught in the Akt.

Abstract

To control cell proliferation, signal transduction needs to regulate the cell-cycle machinery. Recent findings show that Akt - a major kinase that coordinates diverse signalling pathways - phosphorylates Skp2, a subunit of the SCF-Skp2 ubiquitin ligase that targets key cell-cycle regulators. Akt1-dependent phosphorylation activates SCF-Skp2 through multiple mechanisms.

PMID:
19337320
DOI:
10.1038/ncb0409-377
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center