Format

Send to

Choose Destination
Nat Rev Drug Discov. 2009 Apr;8(4):308-20. doi: 10.1038/nrd2830.

Thyroid hormone mimetics: potential applications in atherosclerosis, obesity and type 2 diabetes.

Author information

1
Methodist Hospital Research Institute, F8-044 6565 Fannin, Houston, Texas 77030, USA. JBaxter918@aol.com

Abstract

Thyroid hormones influence heart rate, serum lipids, metabolic rate, body weight and multiple aspects of lipid, carbohydrate, protein and mineral metabolism. Although increased thyroid hormone levels can improve serum lipid profiles and reduce fat, these positive effects are counterbalanced by harmful effects on the heart, muscle and bone. Thus, attempts to use thyroid hormones for cholesterol-lowering and weight loss purposes have so far been limited. However, over the past decade, thyroid hormone analogues that are capable of uncoupling beneficial effects from deleterious effects have been developed. Such drugs could serve as powerful new tools to address two of the largest medical problems in developed countries--atherosclerosis and obesity.

PMID:
19337272
DOI:
10.1038/nrd2830
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center