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FEBS Lett. 2009 Apr 17;583(8):1386-90. doi: 10.1016/j.febslet.2009.03.056. Epub 2009 Mar 29.

Identification of LTR-specific small non-coding RNA in FeLV infected cells.

Author information

1
Cancer Research Center, Department of Medicine, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02458, USA.

Abstract

The U3-LTR region of leukemia viruses transactivates cancer-related signaling pathways through the production of a non-coding RNA transcript although the role of this transcript in virus infection remains unknown. In this study we demonstrate for the first time that an long terminal repeat (LTR)-specific small non-coding RNA is produced from a feline leukemia virus (FeLV)-infected feline cell line. RNA cloning identified this as a 104 base transcript that originates from the U3-LTR region. We also demonstrate that in in vitro assays this LTR-RNA transcript activates NF kappaB signaling. Taken together, our findings suggest a possible role for this LTR transcript in FeLV pathogenesis.

PMID:
19336234
PMCID:
PMC3774839
DOI:
10.1016/j.febslet.2009.03.056
[Indexed for MEDLINE]
Free PMC Article

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