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Curr Oncol Rep. 2009 May;11(3):193-9.

Progress in the treatment of neuroendocrine tumors.

Author information

1
Gastrointestinal Cancer Center, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA. jang@partners.org

Abstract

Traditional treatments for patients with advanced neuroendocrine tumors include surgical debulking, hepatic embolization, somatostatin analogues, and interferon-alpha. Patients with pancreatic neuroendocrine tumors also may benefit from treatment with the alkylating agents streptozocin or temozolomide. In recent years, several promising new approaches have been investigated in patients with advanced neuroendocrine tumors. One such approach has been the use of radiopeptide therapy targeting somatostatin receptors. Additionally, agents targeting the vascular endothelial growth factor pathway and mammalian target of rapamycin have shown preliminary evidence of activity and are currently being evaluated in large randomized studies.

PMID:
19336011
PMCID:
PMC4029419
[Indexed for MEDLINE]
Free PMC Article

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