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Psychol Med. 2010 Jan;40(1):1-4. doi: 10.1017/S0033291709005558.

Not fade away: the HPA axis and depression.

Abstract

Salivary cortisol sampling has confirmed the presence of increased cortisol secretion in depression and has also revealed that some aspects of hypothalamo-pituitary-adrenal (HPA) axis disturbance have trait-like characteristics that may predict the risk of future illness. Persistent hypersecretion of cortisol in individuals vulnerable to depression also has implications for the medical co-morbidities associated with mood disorder. Pharmacological treatments targeted at the HPA axis represent a novel approach to the management of depression and its complications; however, a better understanding of the molecular basis of HPA axis dysfunction in depressed patients will be needed before this promise can be fulfilled.

PMID:
19335939
DOI:
10.1017/S0033291709005558
[Indexed for MEDLINE]

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