[Effect of phenibut on the content of monoamines, their metabolites, and neurotransmitter amino acids in rat brain structures]

Eksp Klin Farmakol. 2009 Jan-Feb;72(1):60-3.
[Article in Russian]

Abstract

Effects of the nootropic drug phenibut, which is a structural analog of gamma-aminobutyric acid (GABA), on the content of monoamines, their metabolites, and neurotransmitter amino acids in brain structures have been studied on Wistar rats. It is established that a single administration of phenibut in a dose of 25 mg/kg (i.p.) produces a statistically significant increase in the content of dopamine metabolite (3,4-dioxyphenylacetic acid) and the retarding amino acid taurine in striatum. At the same time, phenibut did not significantly influence the levels of GABA, serotonin, and dopamine in various brain structures and produce a moderate decrease in the level of norepinephrine in the hippocampus.

MeSH terms

  • 3,4-Dihydroxyphenylacetic Acid / metabolism
  • Animals
  • Biogenic Monoamines / metabolism*
  • Brain / anatomy & histology
  • Brain / drug effects*
  • Brain / metabolism
  • Dopamine / metabolism
  • Male
  • Neurotransmitter Agents / metabolism*
  • Rats
  • Rats, Wistar
  • Serotonin / metabolism
  • Taurine / metabolism
  • gamma-Aminobutyric Acid / administration & dosage
  • gamma-Aminobutyric Acid / analogs & derivatives*
  • gamma-Aminobutyric Acid / pharmacology

Substances

  • Biogenic Monoamines
  • Neurotransmitter Agents
  • 3,4-Dihydroxyphenylacetic Acid
  • Taurine
  • Serotonin
  • gamma-Aminobutyric Acid
  • 4-amino-3-phenylbutyric acid
  • Dopamine