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Brain Res. 1991 Aug 30;558(1):109-11.

Dextromethorphan protects against the neurotoxic effects of p-chloroamphetamine in rats.

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1
Department of Psychiatry, University of Utah School of Medicine, Salt Lake City.

Abstract

Dextromethorphan, an agent that blocks the neuronal-damaging effects of hypoxemia in vitro, was tested for its ability to prevent the neurotoxic effects of p-chloroamphetamine (PCA). Rats were treated with either saline, PCA, dextromethorphan, or the combination of PCA and increasing doses of dextromethorphan. Dextromethorphan provided a dose-related protection against the serotonin (5-HT)-depleting effects of PCA. These observations may offer a clue as to the mechanism responsible for PCA-induced neurotoxicity.

PMID:
1933372
[Indexed for MEDLINE]
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