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Bioorg Med Chem Lett. 2009 May 1;19(9):2562-5. doi: 10.1016/j.bmcl.2009.03.045. Epub 2009 Mar 16.

New Labdane diterpenes as intestinal alpha-glucosidase inhibitor from antihyperglycemic extract of Hedychium spicatum (Ham. Ex Smith) rhizomes.

Author information

1
Natural Products Laboratory, Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500 607, India.

Abstract

Phytochemical investigation of antihyperglycemic extract of rhizomes of Hedychium spicatum led to the isolation of two new labdane type diterpenes 2, 3 along with seven known compounds (1, 4-9). Their structures were established on the basis of NMR (1D and 2D) and mass spectroscopic analysis. The new compound 2 displayed strong intestinal alpha-glucosidase inhibitory activity. Other compounds also displayed varying degree of intestinal alpha-glucosidase inhibitory potential.

PMID:
19332371
DOI:
10.1016/j.bmcl.2009.03.045
[Indexed for MEDLINE]

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