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Neurotherapeutics. 2009 Apr;6(2):402-5. doi: 10.1016/j.nurt.2009.01.021.

The ketogenic diet: proposed mechanisms of action.

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1
Department of Pharmacology and University of Toronto Epilepsy Research Program (UTERP), University of Toronto, Toronto, Ontario M5S 1A8, Canada.

Abstract

The ketogenic diet is a high-fat, low-carbohydrate diet used to treat drug-resistant seizures, especially in children. A number of possible mechanisms of action have been proposed to explain the anticonvulsant effects of the diet. Four of these hypothetical mechanisms are discussed in the present article: the pH hypothesis, the metabolic hypotheses, the amino acid hypothesis, and the ketone hypothesis.

PMID:
19332336
PMCID:
PMC5084220
DOI:
10.1016/j.nurt.2009.01.021
[Indexed for MEDLINE]
Free PMC Article
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