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J Infect Dis. 2009 May 15;199(10):1525-7. doi: 10.1086/598685.

Topically applied recombinant chemokine analogues fully protect macaques from vaginal simian-human immunodeficiency virus challenge.

Author information

1
Tulane National Primate Research Center, Covington, Louisiana, USA.

Abstract

Effective strategies for preventing human immunodeficiency virus infection are urgently needed, but recent failures in key clinical trials of vaccines and microbicides highlight the need for new approaches validated in relevant animal models. Here, we show that 2 new chemokine (C-C motif) receptor 5 inhibitors, 5P12-RANTES (regulated on activation, normal T cell expressed and secreted) and 6P4-RANTES, fully protect against infection in the rhesus vaginal challenge model. These highly potent molecules, which are amenable to low-cost production, represent promising new additions to the microbicides pipeline.

PMID:
19331577
PMCID:
PMC3626081
DOI:
10.1086/598685
[Indexed for MEDLINE]
Free PMC Article

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