Format

Send to

Choose Destination
J Matern Fetal Neonatal Med. 2009 Mar;22(3):233-8. doi: 10.1080/14767050802488220.

An expanded phenotype of maternal SSA/SSB antibody-associated fetal cardiac disease.

Author information

1
The Heart Institute for Children, Hope Children's Hospital, Oak Lawn, IL 60453, USA. cuneo@thic.com

Abstract

OBJECTIVES:

Conventional manifestations of fetal Sjogren's antibodies (SSA/SSB) associated cardiac disease include atrioventricular block (AVB), transient sinus bradycardia, endocardial fibroelastosis (EFE) and dilated cardiomyopathy. We describe other manifestations of cardiac disease.

METHODS:

We describe three fetuses with unique myocardial and conduction system disease.

RESULTS:

One had isolated EFE with subsequent mitral and tricuspid valve chordal avulsion, the second had sinoatrial and infrahissian conduction system disease, and in both, neonatal progression to life threatening disease occurred. The third had sinus node dysfunction and atrial flutter.

CONCLUSION:

These findings expand the clinical phenotype of maternal SSA/SSB antibody associated fetal cardiac disease.

PMID:
19330707
PMCID:
PMC2833315
DOI:
10.1080/14767050802488220
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Taylor & Francis Icon for PubMed Central
Loading ...
Support Center