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Nat Struct Mol Biol. 2009 Apr;16(4):446-8. doi: 10.1038/nsmb.1578. Epub 2009 Mar 29.

CK2alpha phosphorylates BMAL1 to regulate the mammalian clock.

Author information

1
Department of Physiology, Toho University School of Medicine, Tokyo, Japan.

Abstract

Clock proteins govern circadian physiology and their function is regulated by various mechanisms. Here we demonstrate that Casein kinase (CK)-2alpha phosphorylates the core circadian regulator BMAL1. Gene silencing of CK2alpha or mutation of the highly conserved CK2-phosphorylation site in BMAL1, Ser90, result in impaired nuclear BMAL1 accumulation and disruption of clock function. Notably, phosphorylation at Ser90 follows a rhythmic pattern. These findings reveal that CK2 is an essential regulator of the mammalian circadian system.

PMID:
19330005
PMCID:
PMC6501789
DOI:
10.1038/nsmb.1578
[Indexed for MEDLINE]
Free PMC Article

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