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Heart. 2009 Apr;95(8):646-50. doi: 10.1136/hrt.2008.153379.

Immediate clinical and haemodynamic benefits of restoration of pulmonary valvar competence in patients with pulmonary hypertension.

Author information

1
Cardiac Unit, UCL Institute of Child Health and Great Ormond Street Hospital for Children NHS Trust, London, UK.

Abstract

OBJECTIVE:

To analyse the potential benefit of restoration of pulmonary valvar competence in patients with severe pulmonary regurgitation (PR) and pulmonary hypertension (PH) associated with congenital heart disease.

DESIGN:

Retrospective study.

SETTING:

Tertiary paediatric and adult congenital heart cardiac centre.

INTERVENTIONS:

Percutaneous pulmonary valve implantation (PPVI).

PATIENTS:

All patients who underwent PPVI for treatment of PR in the presence of PH (mean PAP >25 mm Hg).

RESULTS:

Seven patients with severe PH as a result of congenital heart disease and severe PR underwent PPVI. The valve implantation procedure was feasible and uncomplicated in all seven cases, successfully abolishing PR. There was a significant increase in diastolic (15.4 (7.3) to 34.0 (8.5) mm Hg; p = 0.007) and mean (29.7 (8.1) to 41.3 (12.9) mm Hg; p = 0.034) pulmonary artery pressures, and an improvement in NYHA functional class (from median IV to median III; p<0.008). Peripheral oxygen saturations rose from 85.9% (11.0%) to 91.7% (8.3%) (p = 0.036). Right ventricular (RV) volumes decreased (from 157.0 (44.7) to 140.3 (53.3) ml/m(2)), while effective RV stroke volume increased (from 23.4 (9.3) to 41.0 (11.6) ml/m(2)). During a median follow-up of 20.3 months (range 1.3-47.5), valvar competence was well maintained despite near systemic pulmonary pressures. None of the valved stents were explanted during follow-up.

CONCLUSION:

Trans-catheter treatment of PR in patients with PH is well tolerated and leads to clinical and haemodynamic improvement, most probably caused by a combination of increased pulmonary perfusion pressures and RV efficiency.

PMID:
19329719
DOI:
10.1136/hrt.2008.153379
[Indexed for MEDLINE]

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