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Int J Infect Dis. 2009 Sep;13(5):e295-8. doi: 10.1016/j.ijid.2009.01.006. Epub 2009 Mar 28.

Carbapenem-resistant Klebsiella pneumoniae endocarditis in a young adult. Successful treatment with gentamicin and colistin.

Author information

1
Department of Clinical Microbiology and Infectious Diseases, Hadassah Hebrew University Medical Center, Kiryat Hadassah, POB 12000, il-91120, Jerusalem, Israel. Benenson@hadassah.org.il

Abstract

INTRODUCTION:

Enterobacteriaceae are rarely the etiologic agents of endocarditis, with Klebsiella species being especially rare. From the end of 2005, isolates of carbapenem-resistant Klebsiella pneumoniae began to appear in various hospitals across Israel, sensitive only to colistin and gentamicin. We present a case of hospital-acquired endocarditis caused by carbapenem-resistant K. pneumoniae in a young adult.

CASE REPORT:

An 18-year-old man with 40% full thickness burns developed acute bacterial endocarditis complicated by embolic myocardial infarction. Carbapenem-resistant K. pneumoniae carrying the blaKPC3 gene was isolated from multiple blood cultures. He recovered fully after antibiotic treatment with colistin and gentamicin.

CONCLUSIONS:

To our knowledge, this is the first reported case of acute bacterial endocarditis caused by carbapenem-resistant K. pneumoniae. The combination of intravenous colistin and gentamicin was effective and resulted in the cure of this patient's endocarditis without the need for surgical intervention.

PMID:
19329345
DOI:
10.1016/j.ijid.2009.01.006
[Indexed for MEDLINE]
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