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Mol Cell. 2009 Mar 27;33(6):669-70. doi: 10.1016/j.molcel.2009.03.002.

Intricate links between ER stress and apoptosis.

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1
Institute of Molecular Biosciences, University of Graz, 8010 Graz, Austria.

Abstract

Bax inhibitor-1 (BI-1) interacts with Bax, neutralizing its proapoptotic activity. In this issue of Molecular Cell, Lisbona et al. (2009) show that BI-1 directly inhibits IRE1alpha, an essential mediator of the UPR, thereby facilitating crosstalk between apoptosis and ER stress pathways.

PMID:
19328058
DOI:
10.1016/j.molcel.2009.03.002
[Indexed for MEDLINE]
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