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Neuroimage. 2009 Jul 15;46(4):1194-9. doi: 10.1016/j.neuroimage.2009.03.035. Epub 2009 Mar 25.

Striatal dopamine D2 binding is related to frontal BOLD response during updating of long-term memory representations.

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Department of Radiation Sciences, Diagnostic Radiology, Umeå University, Sweden.


Multi-modal brain imaging was used to examine the relation between individual differences in resting-state striatal dopamine D2 binding and the magnitude of prefrontal BOLD activation during updating of long-term memory (LTM) representations. Increased activity in the left prefrontal cortex was observed when LTM updating was required, and there was a positive correlation between striatal D2 activity and the magnitude of left prefrontal activity during updating. These findings support predictions from neurocomputational models of a relation of dopaminergic neurotransmission to transient cognitive operations and related brain activity.

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