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Nature. 2009 Mar 26;458(7237):461-7. doi: 10.1038/nature07963.

Principles of ubiquitin and SUMO modifications in DNA repair.

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  • 1Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.

Abstract

With the discovery in the late 1980s that the DNA-repair gene RAD6 encodes a ubiquitin-conjugating enzyme, it became clear that protein modification by ubiquitin conjugation has a much broader significance than had previously been assumed. Now, two decades later, ubiquitin and its cousin SUMO are implicated in a range of human diseases, including breast cancer and Fanconi anaemia, giving fresh momentum to studies focused on the relationships between ubiquitin, SUMO and DNA-repair pathways.

PMID:
19325626
DOI:
10.1038/nature07963
[PubMed - indexed for MEDLINE]
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