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Biopolymers. 1991 May;31(6):605-12.

Conformational analysis of bacitracin A, a naturally occurring lariat.

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  • 1Departament de Química Orgànica, Universitat de Barcelona, Spain.

Abstract

The proton nmr spectra of bacitracin A in H2O and DMSO-d6 have been assigned and the conformational behavior of the peptide in the two solvents has been compared. Although bacitracin A shows a conformational equilibrium between at least two conformations differing in the relative position of the cyclic and linear domains of the molecule, the spectra in water can be interpreted in terms of a preferred conformation in which the linear part is folded over the cyclic moiety and a turn is present around Ile(8)-DPhe(9).

PMID:
1932561
DOI:
10.1002/bip.360310604
[PubMed - indexed for MEDLINE]
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