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Diabetes Care. 2009 Jun;32(6):1023-5. doi: 10.2337/dc09-0207. Epub 2009 Mar 26.

Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance.

Author information

1
Department of Health Sciences, EMGO Institute for Health and Care Research, VU University Amsterdam, the Netherlands.

Abstract

OBJECTIVE:

Coffee consumption has been associated with lower risk of type 2 diabetes. We evaluated the acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance.

RESEARCH DESIGN AND METHODS:

We conducted a randomized crossover trial of the effects of 12 g decaffeinated coffee, 1 g chlorogenic acid, 500 mg trigonelline, and placebo (1 g mannitol) on glucose and insulin concentrations during a 2-h oral glucose tolerance test (OGTT) in 15 overweight men.

RESULTS:

Chlorogenic acid and trigonelline ingestion significantly reduced glucose (-0.7 mmol/l, P = 0.007, and -0.5 mmol/l, P = 0.024, respectively) and insulin (-73 pmol/l, P = 0.038, and -117 pmol/l, P = 0.007) concentrations 15 min following an OGTT compared with placebo. None of the treatments affected insulin or glucose area under the curve values during the OGTT compared with placebo.

CONCLUSIONS:

Chlorogenic acid and trigonelline reduced early glucose and insulin responses during an OGTT.

PMID:
19324944
PMCID:
PMC2681030
DOI:
10.2337/dc09-0207
[Indexed for MEDLINE]
Free PMC Article

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