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Psychoneuroendocrinology. 2009 Aug;34(7):1101-8. doi: 10.1016/j.psyneuen.2009.02.014. Epub 2009 Mar 25.

Anti-inflammatory influences on behavioral, but not cortisol, responses during maternal separation.

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1
Department of Psychology, 335 Fawcett Hall, Wright State University, Dayton, OH 45435, United States.

Abstract

The present study examined the effect of anti-inflammatory agents on the behavioral and plasma cortisol responses of guinea pig pups during isolation in a novel environment. In Experiment 1, intracerebroventricular (i.c.v.) administration of interleukin-10 (IL-10), across a range of doses, significantly reduced passive behaviors of isolated pups. In Experiment 2, neither i.c.v. IL-10 nor alpha-melanocyte stimulating hormone affected the plasma cortisol response to the separation procedure. These results provide further evidence that the passive behaviors of isolated guinea pig pups are mediated by proinflammatory cytokines and indicate that cytokines do not affect behavior indirectly by means of an action on hypothalamic-pituitary-adrenal activity.

PMID:
19324498
PMCID:
PMC2692554
DOI:
10.1016/j.psyneuen.2009.02.014
[Indexed for MEDLINE]
Free PMC Article
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