Evidence of diversification of dengue virus type 3 genotype III in the South American region

Arch Virol. 2009;154(4):699-707. doi: 10.1007/s00705-009-0343-7. Epub 2009 Mar 26.

Abstract

In order to gain insight into the genetic variability of dengue virus type 3 (DENV-3) genotype III isolated in the Latin American region, phylogenetic analysis were carried out using envelope (E) gene sequences from 57 DENV-3 genotype III strains isolated in 11 Latin American countries. At least six different genotype III clades were observed. Amino acids substitutions were found in domain III E protein neutralization epitopes and in surface-exposed domain II and III E protein amino acid sequences.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Amino Acid Substitution / genetics
  • Dengue Virus / classification*
  • Dengue Virus / genetics*
  • Dengue Virus / isolation & purification
  • Epitopes / genetics
  • Genetic Variation*
  • Genotype
  • Humans
  • Latin America
  • Models, Molecular
  • Molecular Sequence Data
  • Phylogeny
  • Protein Structure, Tertiary
  • RNA, Viral / genetics*
  • Sequence Alignment
  • Sequence Analysis, DNA
  • Sequence Homology
  • Viral Envelope Proteins / genetics

Substances

  • E protein, Dengue virus type 3
  • Epitopes
  • RNA, Viral
  • Viral Envelope Proteins

Associated data

  • GENBANK/FM246466
  • GENBANK/FM246467
  • GENBANK/FM246468
  • GENBANK/FM246469
  • GENBANK/FM246470
  • GENBANK/FM246471
  • GENBANK/FM246473