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J Invest Dermatol. 2009 Apr;129(4):820-2. doi: 10.1038/jid.2009.11.

New aspects of nitrite homeostasis in human skin.

Author information

1
Department of Plastic and Reconstructive Surgery, Hand Surgery, and Burn Center, Medical Faculty, RWTH Aachen University, Aachen, Germany.

Abstract

Enzymatic as well as nonenzymatic mechanisms generate nitric oxide (NO) from nitrite in the blood, stomach, saliva, and urine, as well as in the skin. In human skin, the inorganic anions nitrate and nitrite are not inert end products of endogenous nitric oxide metabolism, as long believed, but can be recycled by environmental stimuli such as UVA radiation to form NO; thus, they represent an important alternative nonenzymatic physiological source of NO.

PMID:
19322160
DOI:
10.1038/jid.2009.11
[Indexed for MEDLINE]
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