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Neuroreport. 2009 Apr 22;20(6):553-7. doi: 10.1097/WNR.0b013e3283293e59.

Suppression of adult neurogenesis leads to an increased hypothalamo-pituitary-adrenal axis response.

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1
Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-3711, USA.

Abstract

Stress and glucocorticoids are among the strongest inhibitors of adult hippocampal neurogenesis. Despite the known role of the hippocampus in negative feedback regulation of the hypothalamo-pituitary-adrenal axis, whether the loss of hippocampal neurogenesis affects this inhibition has not been examined. Here we tested whether suppression of adult neurogenesis affected the hypothalamo-pituitary-adrenal axis response. Our results show that suppression of neurogenesis leads to a potentiated hypothalamo-pituitary-adrenal axis response after an exposure to a mild stressor. This study suggests that suppressed neurogenesis regulates the hypothalamo-pituitary-adrenal axis response.

PMID:
19322118
PMCID:
PMC2693911
DOI:
10.1097/WNR.0b013e3283293e59
[Indexed for MEDLINE]
Free PMC Article
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