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J Gen Virol. 2009 Jun;90(Pt 6):1303-18. doi: 10.1099/vir.0.011460-0. Epub 2009 Mar 25.

Rev: beyond nuclear export.

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Department of Medicine, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK.


Rev remains a hot topic. In this review, we revisit the insights that have been gained into the control of gene expression by the retroviral protein Rev and speculate on where current research is leading. We outline what is known about the role of Rev in translation and encapsidation and how these are linked to its more traditional role of nuclear export, underlining the multifaceted nature of this small viral protein. We discuss what more is to be learned in these fields and why continuing research on these 116 amino acids and understanding their function is still important in devising methods to combat AIDS.

[Indexed for MEDLINE]

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