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Curr Biol. 2009 Mar 24;19(6):R262-5. doi: 10.1016/j.cub.2009.02.011.

Innate immunity: cytoplasmic DNA sensing by the AIM2 inflammasome.

Author information

1
Department of Biochemistry, University of Lausanne, Epalinges, Switzerland.

Abstract

Cytoplasmic double-stranded DNA triggers cell death and secretion of the pro-inflammatory cytokine IL-1beta in macrophages. Recent reports now describe the mechanism underlying this observation. Upon sensing of DNA, the HIN-200 family member AIM2 triggers the assembly of the inflammasome, culminating in caspase-1 activation, IL-1beta maturation and pyroptotic cell death.

PMID:
19321146
DOI:
10.1016/j.cub.2009.02.011
[Indexed for MEDLINE]
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