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Curr Biol. 2009 Mar 24;19(6):R234-41. doi: 10.1016/j.cub.2009.02.015.

Binding reactions: epigenetic switches, signal transduction and cancer.

Author information

1
Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 595, New York, NY 10021, USA. m-ptashne@mskcc.org

Abstract

Simple binding interactions lie at the heart of disparate biological functions. Multiple negative and positive 'add-ons', often with small individual effects, make elementary systems that work, work better. Cancer illustrates various of these fundamental processes gone awry.

PMID:
19321137
DOI:
10.1016/j.cub.2009.02.015
[Indexed for MEDLINE]
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