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J Am Chem Soc. 2009 Apr 15;131(14):5014-5. doi: 10.1021/ja900389x.

A microfluidic high-resolution NMR flow probe.

Author information

1
Mesa+ Institute for Nanotechnology, University of Twente, Drienerlolaan 5, 7522 NB Enschede, The Netherlands.

Abstract

A microfluidic high-resolution NMR flow probe based on a novel stripline detector chip is demonstrated. This tool is invaluable for the in situ monitoring of reactions performed in microreactors. As an example, the acetylation of benzyl alcohol with acetyl chloride was monitored. Because of the uncompromised (sub-Hz) resolution, this probe holds great promise for metabolomics studies, as shown by an analysis of 600 nL of human cerebrospinal fluid.

PMID:
19320484
DOI:
10.1021/ja900389x
[Indexed for MEDLINE]

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