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Nat Rev Immunol. 2009 Apr;9(4):235-45. doi: 10.1038/nri2524.

B cells in HIV infection and disease.

Author information

1
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA. smoir@niaid.nih.gov

Abstract

In recent years, intense research efforts have been dedicated to elucidating the pathogenic mechanisms of HIV-associated disease progression. In addition to the progressive depletion and dysfunction of CD4(+) T cells, HIV infection also leads to extensive defects in the humoral arm of the immune system. The lack of immune control of the virus in almost all infected individuals is a great impediment to the treatment of HIV-associated disease and to the development of a successful HIV vaccine. This Review focuses on advances in our understanding of the mechanisms of B-cell dysfunction in HIV-associated disease and discusses similarities with other diseases that are associated with B-cell dysfunction.

PMID:
19319142
PMCID:
PMC2779527
DOI:
10.1038/nri2524
[Indexed for MEDLINE]
Free PMC Article

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