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Curr Opin Cell Biol. 1991 Oct;3(5):817-23.

Extracellular matrix regulation of growth factor and protease activity.

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New York University Medical Center, New York.


Extracellular matrices bind many growth factors, proteases, and protease inhibitors. These interactions not only localize these molecules to the pericellular environment, but also modulate their biological activities. Recent evidence suggests that some growth factors may be active in vivo primarily in complexes with extracellular matrix molecules and that this interaction may be essential to their activity.

[Indexed for MEDLINE]

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