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Clin Exp Immunol. 2009 Jun;156(3):395-404. doi: 10.1111/j.1365-2249.2009.03921.x. Epub 2009 Mar 20.

Translational mini-review series on immunology of vascular disease: mechanisms of vascular inflammation and remodelling in systemic vasculitis.

Author information

1
H. San Raffaele Scientific Institute and Università Vita-Salute San Raffaele, via Olgettina, Milano, Italy.

Abstract

Vessel walls are the primary inflammatory sites in systemic vasculitides. In most cases the initiating event is unknown, and a self-sustaining circuit attracts and activates inflammatory leucocytes in the wall of vessels of various size and anatomical characteristics. Recent studies have revealed homeostatic roles of vascular inflammation and have identified the action of humoral innate immunity, in particular injury-associated signals and acute phase proteins, on the activation of circulating leucocytes, platelets and endothelial cells. These advances have provided clues to the molecular mechanisms underlying the vicious circle that maintains and amplifies vessel and tissue injury.

PMID:
19309348
PMCID:
PMC2691966
DOI:
10.1111/j.1365-2249.2009.03921.x
[Indexed for MEDLINE]
Free PMC Article

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